Equilibrium solubility of ginkgo flavonoid components in water and PBS of different pHs with mass fraction weight coefficient method

Abstract

To descript the equilibrium solubility of ginkgo flavonoid components in water and PBS of different pHs. The HPLC method was adopted to determine the concentration of quercetin, kaempferol and isorhamnetin in ginkgo biloba extracts, and the equilibrium solubility of the three components in water and PBS of different pHs. Furthermore, the mass fraction weight coefficient method was adopted to express the integrated equilibrium solubility and oil-water distribution coefficient of ginkgo flavonoid components. Ginkgo flavonoid components were well dissoluble in water, with the maximum equilibrium solubility of 408.29 mg x L(-1) at pH 7.8. Therefore, it could be preliminarily predicted that ginkgo flavonoid components had higher application value, and could provide guiding basis for further development of preparations. By comparing the results of the direct addition method and the mass fraction weight coefficient method, we found that the mass fraction weight coefficient method was more scientific and reasonable. The tentative study could provide ideas to property characterization of traditional Chinese medicine components.