Abstract
The present study reports the solubilization power of polyethylene glycol dimethyl ether 250 (PEGDME 250) for three poorly water-soluble drugs including 5-aminosalicylic acid, salicylic acid and paracetamol in water medium at 293.15 K to 313.15 K under atmospheric pressure (≈85 kPa) by shake-flask technique followed by spectroscopy. The descending order of the mole fraction solubility of drugs in PEGDME 250 + water solutions as follow: 5-aminosalicylic acid < paracetamol < salicylic acid. It was also found that the solubility of 5-aminosalicylic acid, salicylic acid and paracetamol in this system enhanced with raising temperature and PEGDME 250 mass fraction. The obtained data were fitted using Jouyban-Acree based models, the modified Wilson-van’t Hoff, NRTL, Wilson and UNIQUAC models. The average relative deviations for the back-calculated solubility data were calculated for reporting the accuracy of each model. Moreover, the apparent thermodynamic properties of dissolution and mixing of drugs in PEGDME 250 + water mixtures such as Gibbs free energy, entropy and enthalpy were determined by the help of solubility data, van’t Hoff and Gibbs equations. An endothermic and entropy-driven dissolution process was observed for paracetamol and salicylic acid in PEGDME 250 + water mixtures whereas it was endothermic and enthalpy-driven for the mesalazine in the investigated mixtures.
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