Equilibrium fluctuations of a semiflexible filament cross linked into a network.

Abstract

We examine the equilibrium fluctuation spectrum of a semiflexible filament segment in a network. The effect of this cross linking is to modify the mechanical boundary conditions at the end of the filament. We consider the effect of both tensile stress in the network and its elastic compliance. Most significantly, the network's compliance introduces a nonlinear term into the filament Hamiltonian even in the small-bending approximation. We analyze the effect of this nonlinearity upon the filament's fluctuation profile. We also find that there are three principal fluctuation regimes dominated by one of the following: (i) network tension, (ii) filament bending stiffness, or (iii) network compliance. This work provides the theoretical framework necessary to analyze activity microrheology, which uses the observed filament fluctuations as a noninvasive probe of tension in the network.