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Abstract
Summary In this study, we have used equilibium contrast CMR (EQ-CMR) to assess the interstium volume of patients after atrial redirection surgery, finding higher amounts than in healthy volunteers and correlations with known clinical markers of disease. Background After atrial redirection surgery (the Mustard and Senning operations) for transposition of the great arteries (TGA) the systemic right ventricle (RV) suffers from late systolic failure with resultant high morbidity and mortality. The mechanisms of late systemic RV failure are poorly characterised. We hypothesised that diffuse interstitial expansion representing diffuse fibrosis would be greater in the right ventricles of patients following Mustard or Senning surgery and that it would be associated with other markers of heart failure and disease severity in these patients. Methods
Highlights
After atrial redirection surgery for transposition of the great arteries (TGA) the systemic right ventricle (RV) suffers from late systolic failure with resultant high morbidity and mortality
We hypothesised that diffuse interstitial expansion representing diffuse fibrosis would be greater in the right ventricles of patients following Mustard or Senning surgery and that it would be associated with other markers of heart failure and disease severity in these patients
We used Equilibrium Contrast CMR to quantify interstitial expansion,Vd(m), in the septum and RV free wall of 14 consecutive adults presenting to a tertiary specialist clinic late after palliative surgery for TGA (8 Mustard, 6 Senning, 6 female, median age 33 (IQR: 7))
Summary
Daniel Sado1*, Carla Plymen, Pier Lambiase, Aidan Bolger, Andrew M Taylor, Marina Hughes, James Moon. Summary In this study, we have used equilibium contrast CMR (EQ-CMR) to assess the interstium volume of patients after atrial redirection surgery, finding higher amounts than in healthy volunteers and correlations with known clinical markers of disease
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