Abstract
By sequencing tens of millions of TCRα transcripts from naive mouse CD8 + T cells, Genolet et al (2012) show that the TCRα repertoire is at least as diverse as the TCRβ repertoire. This overturns a long held view in the field that recombination of the Tcra locus occurs in a co‐ordinate sequential bidirectional manner that relies on proximity of Vα and Jα gene segments. The observation that rearrangement of all possible Vα‐Jα combinations can occur is consistent with an alternative model in which intralocus loop formation/locus contraction enables an opportunity for all Vα gene segments to recombine with Jα gene segments.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
