Abstract
It is shown that ddA bis(SATE)phosphotriester is one of the most potent anti-HIV agents m cell culture. Compared with the parent nucleoside, ddA, an increase of 3 orders of magnitude was observed in the EC5o, which makes this compound as active as AZT. This can be tentatively explained if one considers that direct ddAMP intracellular delivery shunts the well established ddA/ddI metabolism pathway.
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