Abstract
Abstract Acute Epstein-Barr virus (EBV) infection is most often associated with a clinical presentation of pharyngitis, fever, lymphadenopathy, and fatigue. There has been a recent recognition of the association of EBV with genital ulcers, predominately in females. Over 100 years ago, Lipschütz (Arch Dermatol Syph (Berlin). 1913;114:363–395) described a series of females with severe genital ulcers, which had 3 suspected causes: herpes simplex virus infection, Behçet syndrome, and what he termed ulcus vulvae acutum (UVA). I wish to present the case of a young female who presented with UVA in the context of an acute EBV infection. The possible pathogenic role of EBV in UVA will be reviewed.
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