Epstein–Barr Virus: The Future for Screening, Treatment and Monitoring of Nasopharyngeal Carcinoma

Abstract

Nasopharyngeal carcinoma (NPC) is often not diagnosed until an advanced stage of the disease, and has a poor 5-year survival with current therapies. Thus, screening programs to identify high-risk patients at early disease stages are essential to improve patient outcomes, most likely through using Epstein–Barr virus (EBV) DNA monitoring in conjunction with tumor-specific markers. EBV-specific cytotoxic T lymphocytes (CTLs) have been utilized successfully for long-term regression of EBV-associated B-cell lymphomas, such as post-transplant lymphoproliferative disease. This strategy has recently been adapted to raise latent membrane proteins 1 and 2, and EBV nuclear antigen 1-specific CD8+and CD4+T cells to target EBV proteins expressed in NPC tumors. Future challenges will be focused on developing multiple-target therapies, including improving CTL persistence and tumor specificity. Understanding the role of EBV infection and protein expression in NPC will be pivotal in the development of screening protocols and novel treatments, including vaccines.