Abstract
Presently available methods for the detection of Epstein-Barr virus, the differentiation of various virus related antigens, and the titration of the corresponding antibodies in human sera are reviewed. Applications of these techniques to the diagnosis of infectious mononucleosis, the determination of immunity to this disease, and seroepidemiologic studies are discussed in general terms with an evaluation of the relative merits of individual test procedures. Results obtained in a recent series of 90 patients with infectious mononucleosis are presented to show that an Epstein-Barr virus specific serodiagnosis can be established in most, if not all, cases, provided the most pertinent tests are performed. The data reaffirm the conclusion that the Epstein-Barr virus is the cause of infectious mononucleosis.
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