Abstract
Serum anti-EBV ab titers determined by immunofluorescent techniques in 27 patients (pts) (ages 3.5-20 yr) with A-T showed elevated anti-viral capsid antigen (ag) (VCA⩾1:320) and anti-early ag (EA⩾1:10) titers in 55% and 48.2% of the pts. Anti-EBV associated nuclear ag (EBNA) titers were low (<1:10). in 44.2%. Comparison with 22 healthy family members, 23 healthy controls, 10 pts with primary immunodeficiency, 10 pts with Behçet's disease showed the geometric mean titers to be 6 fold higher for anti-VCA and 5 fold lower for anti-EBNA than in the healthy controls. Nineteen A-T pts with low anti-EBNA titers had suggestive evidence of greater T cell deficiency than 8 pts with normal anti-EBNA titers,detected by absolute lymphocyte count, skin tests and E rosettes. It is hypothesized that EBNA for maintained ab stimulation is derived from EBV transformed cells by cell mediated anti-cellular reactions.Therefore highly immunosuppressed pts should develop and maintain very low anti-EBNA titers. Low anti-EBNA Ab patterns were also observed in 5 pts with primary immunodeficiency and in 3 pts with Behçet's Disease.
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