Abstract
Primary leptomeningeal lymphoma (PLML) is a rare disorder, and the pathogenesis of it has not been well described [1,2]. We report herein a case of B-cell PLML associated with Epstein–Barr virus (EBV) infection in an old patient. A 73-year-old HIV negative woman experienced a 3-month history of progression of bilateral leg weakness and paresthesias of the bilateral planta pedis. Gadolinium (Gd)-enhanced magnetic resonance imaging showed diffuse thickening of the nerve roots of the cauda equina and enhancement of the dorsal surface of the cervical cord and the root of the right oculomotor nerve (Fig. 1). A cerebrospinal fluid (CSF) examination revealed elevation of the protein concentration (292 mg/dl) and soluble interleukin-2 receptor concentration (3910 U/ml) and of the white blood cell count (224/mm). Polymerase chain reaction (PCR) studies of CSF were negative for cytomegaly,
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