Abstract
Purified horny cell membrane of the epidermis of newborn rat was prepared by discontinuous sucrose density gradient ultracentrifugation after 0.1 n sodium hydroxide treatment. e-(γ-Glutamyl)-lysine cross-link was identified mainly in the horny cell membranes of the epidermis of newborn rat, cow snout, and human stratum corneum. When, [14C]-lysine was incubated with minced epidermis of newborn rat, [14C]-lysine labeled e-(γ-glutamyl)lysine cross-link was identified in purified horny cell membrane. Results indicate that the protein newly synthesized in the granular layer might play a role in the formation of thickened cell membrane in the late stage of the epidermal differentiation.
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