Abstract

Objective: Cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy has been rolled out across Europe for the treatment of Cystic Fibrosis (CF). These new therapies have a predominately positive effect on people with CF (pwCF), improving lung function, weight and reducing pulmonary exacerbations. However, immunogenic reactions to CFTR modulators can occur and may lead to drug discontinuation. We aimed to assess the frequency and severity of these reactions.

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