Abstract
Changes in Fe3+-transferrin (Fe-Tf) and Cu2+-ceruloplasmin (Cu-Cp) concentrations in venous blood sampled from anemic patients with urinary bladder and kidney cancer of stages I–IV were assessed using EPR spectroscopy. In malignancy-associated anemia, the paramagnetic Fe3+ concentration in Tf proved to be below the norm, while in anemic non-oncology patients the Tf iron saturation was normal. Moreover, in patients with malignancy-associated anemia the Cu-Cp on average was nearly twice higher than in healthy volunteers (p < 0.01). Thus, simultaneous EPR measurement of protein-borne paramagnetic centers (such as Fe-Tf and Cu-Cp) in the blood of anemic patients can be used as an express biomarker for urological cancer even at early stages of malignant growth.
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