EPR analysis of dosimetric properties of various organic materials for radiotherapy applications

Abstract

Introduction Electron Paramagnetic Resonance (EPR) spectroscopy is a sensitive, precise and nondestructive technique. It is used in this study to analyze alanine, sugar and glucose irradiated by electrons. These materials are available and nontoxic, their irradiation produces free radicals in which the concentration is relatively proportional to the absorbed dose. In this work, we analyze and compare the dosimetric properties of these materials with the aim of using them for in vivo dosimetry in radiotherapy. Purpose In this study we compare the dosimetric properties after electron irradiation of alanine, sugar and glucose, by considering their sensitivity to irradiation, the shape of obtained dosimetric curves and the stability of EPR spectra during storage period. Materials and methods Several samples of alanine, sugar and glucose are irradiated by 6 MeV electrons (Dose range: 0–20 Gy) provided by a linear accelerator “Clinac 2300DHX” used in radiotherapy care. After irradiation, EPR measurements on samples are undertaken using a “Magnettech – MS400” spectrometer. These measurements are processed using peak to peak and double integration methods. Results Suitable sensitivity to irradiation observed for the used materials (Threshold dose: alanine, 1 Gy; sugar, 1.5 Gy; glucose, 2 Gy), •Good linearity of dosimetry curves in the dose range used. •Weak fading of EPR signal during storage period after irradiation especially in the case of alanine and sugar. Conclusion In this preliminary study, the obtained results showed that alanine and sugar are very promising materials for their applications in in vivo dosimetry in radiotherapy. Disclosure Authors do not have any relationships with commercial entities to disclose. Electron Paramagnetic Resonance (EPR) spectroscopy is a sensitive, precise and nondestructive technique. It is used in this study to analyze alanine, sugar and glucose irradiated by electrons. These materials are available and nontoxic, their irradiation produces free radicals in which the concentration is relatively proportional to the absorbed dose. In this work, we analyze and compare the dosimetric properties of these materials with the aim of using them for in vivo dosimetry in radiotherapy. In this study we compare the dosimetric properties after electron irradiation of alanine, sugar and glucose, by considering their sensitivity to irradiation, the shape of obtained dosimetric curves and the stability of EPR spectra during storage period. Several samples of alanine, sugar and glucose are irradiated by 6 MeV electrons (Dose range: 0–20 Gy) provided by a linear accelerator “Clinac 2300DHX” used in radiotherapy care. After irradiation, EPR measurements on samples are undertaken using a “Magnettech – MS400” spectrometer. These measurements are processed using peak to peak and double integration methods. Suitable sensitivity to irradiation observed for the used materials (Threshold dose: alanine, 1 Gy; sugar, 1.5 Gy; glucose, 2 Gy), •Good linearity of dosimetry curves in the dose range used. •Weak fading of EPR signal during storage period after irradiation especially in the case of alanine and sugar. In this preliminary study, the obtained results showed that alanine and sugar are very promising materials for their applications in in vivo dosimetry in radiotherapy.