EPN-37PAEDIATRIC SPINAL EPENDYMOMA IN CANADA: A MULTICENTRE RETROSPECTIVE STUDY

Abstract

EPN-37. PAEDIATRIC SPINAL EPENDYMOMA IN CANADA: A MULTICENTRE RETROSPECTIVE STUDY Bjorn Baadjes1, Sylvia Cheng1, Paul Steinbok1, Jim Potts1, Karen Goddard2, Tamir Ailon3, Uri Tabori4, Anne-Sophie Carret5, Daniel McNeely6, David Eisenstat7, Beverly Wilson7, Donna Johnston8, Shayna Zelcer9, Katrin Scheinemann10, Christopher Dunham1, and Juliette Hukin1; British Columbia Children’s Hospital, Vancouver, BC, Canada; British Columbia Cancer Agency, Vancouver, BC, Canada; Vancouver Hospital and Health Sciences Centre, Vancouver, BC, Canada; The Hospital for Sick Children, Toronto, ON, Canada; Sainte-Justine Hospital, Montreal, QC, Canada; IWK Health Centre, Halifax, NS, Canada; Stollery Children’s Hospital, Edmonton, AB, Canada; Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada; Children’s Hospital of Western Ontario, London, ON, Canada; The University Hospital Munster, Munster, NRW, Germany BACKGROUND: Ependymomas in children are predominantly located intracranially, with spinal cord ependymomas being rare. Our objective was to determine long-term outcomes of our Canadian paediatric cohort with spinal ependymoma. METHODS: This retrospective multicentre study analysed diagnosis, treatment and outcome of spinal ependymoma patients treated at 9 paediatric oncology centres in Canada between 1986 and 2006. RESULTS: Thirty-six children (20 male), median age 11.9 years (interquartile range 9.1 to 14.4 years), were identified. Length of follow-up was 72.8 months (34.6 to 108.4 months). Thirty-one patients (86%) had WHO grade I disease (all myxopapillary ependymoma located in cauda equina), while 5 (14%) had WHO grade 2 disease. Twenty-fiveof 36 patients (69%) underwent gross total resection (GTR) of tumour, with 11/36 (31%) patients having incomplete resections. Six patients received focal adjuvant radiation therapy. Twelve of 36 (33%) relapsed, with a median time to relapse of 27 months. Six of 25 patients (24%) with GTR relapsed, while 6/11 (55%) patients with incomplete resectionrelapsed.Amongrelapsedpatients, 9underwent further surgery (4GTR,4 incomplete resection, 1 unknown) and 8 had adjuvant radiation therapy. There was no statistical difference in WHO grade and whether adjuvant radiation therapy was administered at diagnosis between relapse and non-relapse patients. Seventeen patients (47%) were disease-free, 18 (50%) were alive with disease, and tumour status on one patient was unknown. One patient died of the disease. CONCLUSIONS: Spinal ependymoma in children is rare, but overall survival outcomes are excellent despite some children suffering recurrence. Neuro-Oncology 18:iii30–iii39, 2016. doi:10.1093/neuonc/now070.36 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.