Abstract
Hypothermia can develop due to environmental or nonenvironmental factors. Episodic spontaneous hypothermia with hyperhidrosis (ESHH) is a rare cause of nonenvironmental hypothermia in which the core temperature is less than 350C and is characterized by episodes of hypothermia and sweating without shivering. Although the episodes are usually short, cases with persisting episodes for months have been reported. The pathophysiology of episodic spontaneous hypothermia with hyperhidrosis is unknown. Patients with agenesis of corpus callosum have been described as the Shapiro's syndrome. There is no definitive treatment for epidosic spontaneous hypothermia with hyperhidrosis. Antiepileptic, antiserotonergic agents have been reported to be effective to control episodes in some patents. We presented a patient with ESHH without corpus callosum agenesis who was treated with cyproheptadine.
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