Epithelioid Glioblastoma with Leptomeningeal Gliomatosis – Case Report and Review of the Literature

Walid Albanna

doi:10.26717/bjstr.2018.10.001920

Abstract

Epithelioid Glioblastoma with Leptomeningeal Gliomatosis – Case Report and Review of the Literature

Highlights

Glioblastomas are the highest-grade malignant brain tumors within the spectrum of astrocytic neoplasms [1,2]
epithelioid glioblastoma (E-GBM) should be considered in the case of Magnetic resonance imaging (MRI) findings without peripheral edema, and when newly diagnosed intracerebral masses arise without a known primary
Additional immunohistochemistry showed positive staining for glial fibrillary acidic protein (GFAP) and epithelial membrane antigen (EMA) (Figure 3); the tumor was diagnosed as an E-GBM

Summary

Introduction

Glioblastomas are the highest-grade malignant brain tumors within the spectrum of astrocytic neoplasms [1,2]. Epithelioid glioblastomas (E-GBMs) are a rare subtype characterized by a cohesive architectural organization in epithelioid nests and sheets. This phenotype can obscure the glial lineage and may mimic metastatic involvement of non-CNS neoplasms because of epithelial-like characteristics [1,3,4,5]; E-GBMs remain a considerable diagnostic challenge. Many reports have described these unusual glioblastomas as solitary lesions [6,7]. Magnetic resonance imaging (MRI) showed a contrastenhancing lesion in the left temporal lobe without significant surrounding edema, suggesting the presence of a cerebral metastasis (Figure 1). An early post-operative MRI showed complete resection of the contrast-enhancing lesion.

Pathological Findings

Discussion

Conclusion