Abstract
Angiosarcoma of bone is an exceedingly rare primary bone malignancy that can present as an aggressive osteolytic lesion. This subset can radiologically mimic non-vascular neoplasms and impose serious challenges in reaching the correct diagnosis. Meanwhile histological diagnosis can be extremely challenging too, as the pathological features often resemble that of aneurysmal bone cysts. We present an unusual case of a 22-year-old woman who presented with a rapidly growing humeral tumor of 8 months’ duration. The case of intraosseous angiosarcoma presented as a diagnostic dilemma and the relevant radiological and pathologic findings were discussed. We describe the clinical, radiological and pathological features of this unique case, and review the literature concerning Angiosarcoma of bone. Our case highlights the diagnostic difficulties for such very rare tumours and clinico-pathological correlation is of paramount importance to differential diagnosis.
Highlights
Angiosarcoma is an uncommon neoplasm characterized by rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and lining irregular blood-filled spaces
Angiosarcoma of bone is an exceedingly rare primary bone malignancy that can present as an aggressive osteolytic lesion
Histological diagnosis can be extremely challenging too, as the pathological features often resemble that of aneurysmal bone cysts
Summary
Angiosarcoma is an uncommon neoplasm characterized by rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels and lining irregular blood-filled spaces. Angiosarcomas are aggressive and tend to recur locally and spread widely [1]. 6% of all angiosarcomas are found in bone [2]. Primary angiosarcoma arising in bone is very rare, and accounts for less than 1% of malignant bone tumours [3]. Skeletal angiosarcoma generally affects young adults and elderly individuals, with a 2 1 male to female ratio [4]. The bones of the lower limb, the femur and tibia, are most commonly involved, followed by pelvis, vertebral column and bones of the upper limb [4]
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