Abstract
Chorioallantoic membrane (CAM) is formed through fusion of the chorion and allantois in amniote early development. The CAM mediates oxygen and calcium uptake in birds and gives rise to fetal part of the placenta in mammals. Molecular mechanism regulating CAM fusion is poorly understood. We carried out cellular and molecular analyses of CAM fusion between E3.5 and E4.5 of chicken development. we show that CAM fusion is preceded by a brief period of contact between chorionic and allantoic mesothelia (two mesoderm‐derived epithelial structures) followed by their EMT and subsequent integration. We identified molecular (EMT‐related and non‐EMT‐related) markers specific to each tissue layer during CAM fusion. We will also discuss our data on canonical (SNAI1 and ZEB2) and non‐canonical (WT1) EMT‐associated transcription factors in driving mesothelial EMT. We propose that avain CAM fusion is a new model for studying mesothelial cell EMT, which is known to play important physiological (e.g., placenta formation) and pathological (e.g., mesothelioma and ovarian cancer) roles in the human.Support or Funding InformationIRCMS, Takeda Science Foundation, JSPS
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