Abstract
A distinctive feature of polarized epithelial cells is their specialized junctions, which contribute to cell integrity and provide platforms to orchestrate cell shape changes. The chapter discusses the composition and assembly of C. elegans cell-cell and cell-extracellular matrix junctions, proteins that anchor the cytoskeleton and mechanisms involved in establishing epithelial polarity. The focus remains cellular and does not properly deal with epithelial cells in the context of the developing embryo.
Highlights
The interest in epithelial junctions and their associated cytoskeletal elements is recent
For developmental aspects or for a more comprehensive coverage of cell adhesion, the reader should consult the chapter on Epidermal morphogenesis and reviews (Cox et al, 2004; Ding et al, 2004)
PAR-3, PAR-6 and PKC-3 are present at the apical membrane of tubular organs, where their role has been difficult to assess owing to their early requirement in development (Pellettieri and Seydoux, 2002)
Summary
The interest in epithelial junctions and their associated cytoskeletal elements is recent. None of the genes mentioned in this chapter were known, let alone discussed, when C. elegans II was released. This chapter introduces the main players, and addresses cell adhesion, cytoskeletal anchoring, epithelial polarity and fibrous organelle assembly with a focus on cellular function. For developmental aspects or for a more comprehensive coverage of cell adhesion, the reader should consult the chapter on Epidermal morphogenesis and reviews (Cox et al, 2004; Ding et al, 2004)
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