Abstract

Clusters of benign epithelial cells or structures, most often glands, within a lymph node are thought to represent remnants of embryonic structures that terminally differentiate and remain quiescent in lymph nodes (developmental heterotopia), or more rarely result from ruptured structures that float into lymph nodes from neighboring organs. The most common epithelial inclusions within lymph nodes are found in the head and neck, axillary, paraaortic, and pelvic regions. Most important from the clinical standpoint, epithelial inclusions must be distinguished from metastatic deposits in lymph nodes, which are significantly more commonly found during surgical or staging procedures.

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