Abstract
Epistatic Relationships in the BRCA1-BRCA2 Pathway
Highlights
In modern molecular genetics, epistasis analysis is a tool for probing the relationship between two genes and, between the two genes’ products
In the early days of work on BRCA1 and BRCA2, as their roles in homologous recombination (HR) were beginning to come into focus, several studies indicated that Brca null mice die in utero around E7.5 (Brca12/2) or E8.5 (Brca22/2)
Breast/ovarian cancer risk and the responsiveness of BRCA-linked cancers to poly(ADP) ribose polymerase (PARP) inhibitors are reflections of HR functions shared by BRCA1 and BRCA2
Summary
Epistasis analysis is a tool for probing the relationship between two genes and, between the two genes’ products. Epistasis analysis has provided useful insights into the quite complex gene relationships that constitute the BRCA1/ BRCA2 pathway of homologous recombination (HR). Differences between BRCA1 and BRCA2 have emerged from studies of their molecular function.
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