Abstract
Epistasis is genetic phenomenon that is defined by an interaction of genetic variation at two or more loci to produce a phenotypic outcome that is not predicted by the additive combination of effects attributable to the individual loci. Phenotypic effects may be qualitative, as in synthetic lethal interactions, or quantitative. Epistasis analysis can be used to order steps in biochemical pathways or to partition genetic variance in populations. Epistatic interactions can provide insight into molecular and evolutionary mechanisms that determine phenotypes in individuals and in populations.
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