Epileptiform activity index for the evaluation of treatment efficacy in patients with epileptic encephalopathy

Abstract

Continuous spike and waves during sleep (CSWS) may lead to different cognitive, motor and behavioral symptoms. CSWS is characterized by an electroencephalography (EEG) pattern of electrical status epilepticus during sleep (ESES). The article reviews the main criteria of ESES, localization of EEG-changes and main EEG-patterns. An analysis of abnormal neuroimaging findings in patients with ESES was performed. The main pathophysiologic theories of ESES pattern formation are reviewed. ESES diagnosis is usually based on rough visual assessment of the number of spikes and waves, but other methods of assessment are also utilized, including spike-wave index (SWI), which is widely used in clinical practice. SWI reflects the percentage of sleep covered with spikes and waves. Two different strategies of SWI calculation are used, but none of them is officially validated. Moreover, there is no consensus on the period of sleep to be used for the calculation of SWI. The article presents a detailed review of calculation and utilization of SWI. It is concluded that further research is needed to develop an optimal algorithm of SWI calculation.