Abstract
Generalised spike-wave discharges (SWD), detectable on the electroencephalogram (EEG), are a hallmark of typical absence seizures. Several mechanisms of transmission have been proposed for SWD seizures including the centrencephalic theory, the corticoreticular theory, and the cortical focus theory [1]. Experimental evidence suggests that seizures rapidly generalise through corticocortical and thalamo-cortical pathways from an excitable cortical ‘focus’ [1]. Further evidence for a cortical focus comes from recent experimental results which show
Highlights
Generalised spike-wave discharges (SWD), detectable on the electroencephalogram (EEG), are a hallmark of typical absence seizures
* Correspondence: ptaylor@ntu.edu.sg 1School of Electrical & Electronic Engineering, Nanyang Technological University, Singapore Full list of author information is available at the end of the article that stimulations to different cortical regions can elicit generalised SWD, the amplitude of the required stimulus varies from one region to another [2]
Based on known anatomical connectivity between the thalamus and cortex (Figure. 1A), we develop a macroscopic model of transitions between inter-ictal and ictal SW dynamics to investigate the cortical focus theory
Summary
Generalised spike-wave discharges (SWD), detectable on the electroencephalogram (EEG), are a hallmark of typical absence seizures. * Correspondence: ptaylor@ntu.edu.sg 1School of Electrical & Electronic Engineering, Nanyang Technological University, Singapore Full list of author information is available at the end of the article that stimulations to different cortical regions can elicit generalised SWD, the amplitude of the required stimulus varies from one region to another [2].
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