Abstract
To the Editor: I read with interest the article by Carter et al., “Increased Prevalence of Epilepsy Associated with Severe Falciparum Malaria in Children” (Epilepsia 2004;45:978-81). I call attention to the possible pathogenesis of epilepsy in malaria. Epilepsy has long been recognized as a late complication of cerebral malaria. Generalized tonic–clonic seizures as well as partial motor seizures have been recorded (1). In fatal cases, pathological examinations of the brain in late stages have shown the malaric granuloma of Durck formed by an astroglial reaction (2). It is conceivable that these lesions may act as an epileptogenic foci in those who survive, giving rise to chronic epileptic seizures.
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