Abstract
Serum of normal volunteers and serum of epileptic patients receiving either a single drug or combined antiepileptic therapy with Phenytoin (Phen); Carbamazepine (Cbz); Primidone (Prim); Phenobarbital (Phb) were examined and showed: 1.1. No differences with regard to total proteins, albumins and A/G ratio.2.2. The α1-globulin fraction increased to 4.4% with Phen/Cbz (P < 0.001) and decreased to 1.7% with Phen/Prim = (P < 0.001).3.3. The α2-globulins corresponded to 7.2% (P < 0.001) with Phen/Prim and 15.5% (P < 0.001) with Phen/Phb treatments.4.4. β-Globulins decreased to 7.1% (P < 0.05) when received Phen/Phb treatment.5.5. Low concentrations of serum γ-Globulins were found in Phb (P < 0.001), Prim (P < 0.001, Phen (P < 0.001) treated patients. However, with Cbz, Phen/Phb, Phen/Prim this electrophoretic fraction remained within the upper range of normal.6.6. IgA of patients treated with Phen showed a mean of 60 mg/dl. Those patients with Phen serum levels below or above 12–20 μg/ml remained normal. Prim and Phb treatment also decreased IgA.7.7. IgD was normal in patients treated with Phen/Prim.8.8. Alterations of immune humoral responses to all antiepileptic drugs were found.
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