Abstract
Frank Morrell played a crusading role in raising the awareness of the potentially detrimental neuroplastic consequence of uncontrolled seizures through his model of secondary epileptogenesis. With the preceeding in mind, comparative data on amygdaloid (AM) and some neocortical kindling in five different primates originating from diverse regions of the world are selectively reviewed. To provide some perspective on primate kindling, this chapter comments on the role of phylogenesis in seizure development, a general profile of primate kindling, and the potential anatomical substrate underlying landmark ictal events. The chapter also discusses the comparative features of AM kindling in live primate species and the differential durability between AM and neocortically kindled epileptogenesis.
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