Epilepsy and pregnancy

Abstract

Regarding treatment of women of childbearing potential with epilepsy, several aspects of family planning and desire to have children have to be taken into account. Overview of current data on mutual implications of epileptic seizures, antiseizure medication (ASM), pregnancy and child development. Review of the current literature, discussion and presentation of resulting treatment recommendations. Many ASMs bear the potential for clinically relevant interactions with both contraceptives and altered concentrations of sexual hormones and modified pharmacokinetics during pregnancy. All ASMs show an increased risk for congenital malformations; however, due to seizure-related risks for the mother and child effective ASM treatment during pregnancy is crucial. When considering the special aspects of consultation and treatment of women of childbearing potential with epilepsy most pregnancies are uncomplicated.