Abstract
Epilepsy was a well-recognized disease in pre-Columbian America, as appears from the reports of the Spanish chroniclers of the sixteenth century. Both the Aztecs and the Incas strongly associated epilepsy with magic and religion, which is evident from their ideas about the pathogenesis and treatment of the disease. Apart from treatment of epilepsy by magic means, the Incas and especially the Aztecs used in addition a large number of botanic medicines; the use of these medicines probably had an empiric nature.
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