Abstract

The relationship between hippocampal cell loss and mossy fiber sprouting (MFS), and the occurrence of spontaneous seizures (epilepsy) following early-life status epilepticus was investigated in laboratory studies at the Division of Neurology, Children’s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA.

Highlights

  • FC risk factors may have an affinity to the right hemisphere. (Janszky J, Woermann FG, Barsi P et al Neurology April 8, 2003;60:1209-1210)

  • The relationship between hippocampal cell loss and mossy fiber sprouting (MFS), and the occurrence of spontaneous seizures following early-life status epilepticus was investigated in laboratory studies at the Division of Neurology, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA

  • The extension of these studies to effects of early-life experimental febrile seizures induced by artificial fever on later development of hippocampal pathology and epilepsy would be of interest

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Summary

Introduction

FC risk factors may have an affinity to the right hemisphere. (Janszky J, Woermann FG, Barsi P et al Neurology April 8, 2003;60:1209-1210). The relationship between hippocampal cell loss and mossy fiber sprouting (MFS), and the occurrence of spontaneous seizures (epilepsy) following early-life status epilepticus was investigated in laboratory studies at the Division of Neurology, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA. Epilepsy after early-life seizures can be independent of hippocampal injury.

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