Abstract
Oral squamous cell carcinoma (OSCC) is an unpredictable disease with poor survival. Biomarker studies using genomic or expression signatures have been unsuccessful in producing a clinically robust biomarker. However, these studies have not focused on epigenomic signatures. Furthermore, they have used heterogeneous cohorts, combining patients of different stages and different tobacco use patterns. In this study we determine an epigenetic and gene expression signature that differentiates between patients with different tobacco use history (heavy tobacco use with ≥10 pack years vs.
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