Abstract
The harmonious regulation of bodily function is a necessity for healthy individuals. Looking from the viewpoint of material sciences, one can only marvel at the cellular factories, their renewal, and the overall control of messaging and control of responses. As aging progresses and/or pathologies arise, clinicians may be forced to look for replacement of organs/tissues with medical devices. Since all devices are tailored, a detailed understanding of developmental processes, including aberrant processes leading to pathologies, is crucial to provide clinicians with a suitable device. Although research in the field of epigenetics has produced effective therapeutics and diagnostic markers, our currently fragmented understanding of epigenetic processes as they relate to material development is inherently limited, with logical implications for the success of medical procedures. Here, we illustrate how material sciences for clinical applications, critically depend on all aspects of biomedical sciences, including the field of epigenetics.
Highlights
Diverse methodologies and study groups hinder present-day extraction of structured knowledge from individual studies to clarify the influence of epigenetic phenomena on the performance of dental
It is apparent that our fragmented understanding of how cells sense their environment, such as through biophysical and dissolved cues, as individual classes of stimuli and their interplay with other signaling pathways, can best be illustrated by a surgeon’s choice of procedures to aid wound healing in hernia-type lesions on the one hand and an apparent paucity of formal studies to illuminate the phenomena involved on the other [19]
Where do we go from here? Do we throw up our hands and leave this topic alone? Emerging evidence connecting epigenetic phenomena with clinical needs, far from being adequately addressed, leaves no alternative but getting to the bottom of all this
Summary
Reducing the posed question of providing personalized devices to patients in need to a more generalized problem of development forces one to concede that the literature does not provide a simple and straightforward answer. Generalizations across species are not encouraged, nor is there a consensus on an understanding of apparently dualistic phenomena, termed ‘repeatability of development’ and ‘inverse of developmental noise’ [1].
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