Abstract
Epigenetics is a gene regulation mechanism that does not depend on genomic DNA sequences, but depends instead on chemical modifications of DNA and histone proteins. [...].
Highlights
It has been recently reported that the number of children with neurodevelopmental disorders (NDs) has increased in several countries, such as the US, Korea, and Japan, in which environmental factors, rather than genetic factors, are thought to be involved in this increase
Since epigenetic modifications in DNA are more vulnerable than DNA sequences to environmental stressors such as malnutrition, environmental chemicals, and mental stress, especially during the early period of life, one can speculate that current socioenvironmental factors cause acquired NDs via epigenetic alterations in the brain [5,6,7]
Epigenomic-based preemptive medicine that consists of early detection using epigenomic signatures and early interventions that take advantage of the use of epigenomic reversibility are expected
Summary
It has been recently reported that the number of children with NDs has increased in several countries, such as the US, Korea, and Japan, in which environmental factors, rather than genetic factors, are thought to be involved in this increase. Since epigenetic modifications in DNA are more vulnerable than DNA sequences to environmental stressors such as malnutrition, environmental chemicals, and mental stress, especially during the early period of life, one can speculate that current socioenvironmental factors cause acquired NDs via epigenetic alterations in the brain [5,6,7]. The epigenome has a reversible property since it is based on removable residues on genomic DNA.
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