Abstract
The pathogenesis of uterine fibroids, the most common benign tumor in women, remains unclear. Environmental factors such as obesity, hypertension, and early menarche place women at greater risk for uterine fibroids. Epigenetic processes such as DNA methylation, histone modification, and microRNA expression play key roles in regulating gene expression and have been shown to be affected by environmental and other factors. Thus, uterine fibroids may be associated with epigenetic abnormalities caused by unfavorable environmental factors.
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