Abstract
The presence of an N1 methyl group on adenine bases in DNA and RNA was thought to be a form of damage. Results now show that it also occurs at specific sites in messenger RNAs, where it affects protein expression. See Article p.441 The N6-methyladenosine (m6A) modification of RNA has been subject to intensive examination since it was recognized to be widespread throughout the transcriptome. In a new study by Chuan He and colleagues, the significance of a different messenger RNA modification, N1-methyladenosine (m1A), is probed on the transcriptome-wide level. Although the modification is dynamic, they find it accumulates in structured regions surrounding both canonical and alternative translation initiation sites, and its presence correlates with higher protein expression.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
