Abstract
Epigenetic reprogramming in the mammalian germline.
Highlights
The role of the germline is to transmit genetic and epigenetic information from one generation to the
The dynamics of DNA methylation reprogramming in mouse Primordial germ cells (PGCs) was first established by Seisenberger et al in 2012 [1]
In a second comprehensive study Kobayashi et al used a post-bisulfite adaptor tagging (PBAT) method with scaled-down amounts of DNA from mouse germ cells at E10.5 to E16.5 [2]. This group observed a similar pattern of global DNA demethylation and de novo methylation during PGC development
Summary
The role of the germline is to transmit genetic and epigenetic information from one generation to the next. The dynamics of DNA methylation reprogramming in mouse PGCs was first established by Seisenberger et al in 2012 [1]. The CpG methylation level in E6.5 epiblasts was 71%, close to the 74% in embryonic stem cell (ESCs), and droped globally during PGC expansion and migration.
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