Abstract
The reciprocal interactions among the different embryonic kidney progenitor populations lay the basis for proper kidney organogenesis. During kidney development, three types of progenitor cells, including nephron progenitor cells, ureteric bud progenitor cells, and interstitial progenitor cells, generate the three major kidney structures—the nephrons, the collecting duct network, and the stroma, respectively. Epigenetic mechanisms are well recognized for playing important roles in organism development, in fine‐tuned control of physiological activities, and in responses to environment stimuli. Recently, evidence supporting the importance of epigenetic mechanisms underlying kidney organogenesis has emerged. In this perspective, we summarize the research progress and discuss the potential contribution of novel stem cell, organoid, and next‐generation sequencing tools in advancing this field in the future.
Highlights
The kidney is responsible for maintaining homeostasis
Epigenetics are involved in regulating several physiological processes, such as cell differentiation,[6] organogenesis,[7] immune response,[8] and organism aging.[9]
We focus on discussing the recent findings of epigenetic regulation of kidney progenitor cell fates during kidney development (Figure 1)
Summary
The kidney is responsible for maintaining homeostasis. It is involved in removing metabolic waste products and adjusting water, salt, and pH to maintain the homeostatic balance of fluids in mammals.[1]. Several research groups have tried to investigate the molecular mechanisms underlying NPCs self-renewal and differentiation during kidney development through epigenetic regulation.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
