Abstract
The hallmark of epithelial-mesenchymal transition (EMT) is the loss of E-cadherin. The downregulation of E-cadherin can be mediated by its transcriptional repression through the binding of EMT transcription factors to the E-cadherin promoter. Epigenetic mechanisms including DNA methylation, histone code and microRNAs are involved in the regulation of EMT-related genes. Studies have shown that EMT transcription factors can cooperate with several epigenetic modifiers to participate in the expression of E-cadherin. Targeting epigenetic regulation of EMT represents a new promising therapeutic direction. Key words: DNA methylation; MicroRNAs; Histone code; Epithelial-mesenchymal transition
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