Abstract
DNA methylation is an important epigenetic modification that causes heritable changes in gene expressions without alterations in DNA sequences. It has been reported that aberrant DNA methylation may play an important role in the development of allergic reactions, but it is unclear how aberrant DNA methylation patterns play their biological roles in these diseases. This article reviews regulation mechanisms of DNA methylation in the occurrence of common allergic reactions or diseases, such as atopic dermatitis, contact dermatitis, urticaria and food allergy, which may help to better understand genetic regulatory mechanisms and gene-environment interaction in the occurrence of these entities. Moreover, DNA methylation studies may provide new directions in the prevention, diagnosis and management of allergic reactions. Key words: Anaphylaxis; DNA methylation; Epigenomics; Dermatitis, atopic; Dermatitis, contact; Urticaria
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