Abstract
This chapter is aimed to focus on the multi-disciplinary nature of Retinoic acid receptor β2 (RARβ2) gene in breast cancer (BC) and highlighting the basic information as an evolutionay insight. The antiproliferative and proapoptotic capacities of Retinoids, derivatives of vitamin, play the crucial role in biological processes and chemopreventive agents against BC. Cause of the pyramid growth and progression in cancers has its roots in minor subpopulations of cancer stem cells. It is highlighted that in cancer stem cell model, the classical structure of tumorigenic and nontumorigenic cells is due to the native epigenetic diversity within the cancer cell populations. Altered expression of RARβ2 could lead to tumorigenesis and retinoid resistance. Hypermethylation of RARβ2 interact with ERα/PR/HER2 as a triangle target genes in BC patients. Different environmental factors are considered as predisposing/stimulator factors for methylation in ERα gene. Cancer family history as a preliminary risk factor, was inversely associated with the hypermethylated RARβ2.
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