Year-end Sale % OFF 
Abstract
The characterisation of the lymphoma epigenome has provided insight into mechanisms involved in lymphomagenesis. Multiple lymphoma subtypes demonstrate recurrent mutations in key epigenetic regulators that have been utilised to define clinicogenetic groups that can predict clinical behaviour in these heterogenous entities. The high frequency of mutations in epigenetic regulators provides rationale to incorporate these in the classification of some subtypes of lymphoma. In addition, their recurrent nature provides a rationale to target such mutations, or the relevant pathway, for treatment. In this review, we summarised the available literature on epigenetic dysregulation in lymphoma and how it has been utilised in diagnosis and classification.
Highlights
Epigenetics describes the modification of the transcription of genetic code independent of the DNA sequence
Epigenetic dysregulation occurs through a complex interplay of different mechanisms, including somatic mutations in key proteins involved in DNA methylation and histone acetylation, deacetylation, and methylation
follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL), in particular, are enriched for mutations of histone modifiers, while, in other subtypes, methylation profiles can be reflective of disease biology; epigenetic mutations have been shown to contribute to clinical behaviour
Summary
Epigenetics describes the modification of the transcription of genetic code independent of the DNA sequence. The development of rapid and accurate gene sequencing technologies, such as generation sequencing (NGS), has led to the use of mutational profiling as an integral component of lymphoma classification; mutations of epigenetic genes are frequently encountered The detection of these epigenetic aberrancies may be useful diagnostically, as certain mutational profiles are supportive of a particular diagnosis. There is an emerging recognition that patterns of epigenetic dysregulation, which are often reflective of the underlying stage of differentiation, can be prognostically relevant; specific epigenetic mutations have been incorporated into prognostic scores [3] Certain lymphoma subtypes, such as follicular lymphoma (FL), have a significant degree of epigenetic dysregulation, which likely drives lymphomagenesis and disease progression.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
