Epigenetic Modifications and Diabetes: Unraveling the Interplay between Genetics, Lifestyle, and Disease Progression

Abstract

Epigenetic modifications are increasingly recognized as critical factors in the pathogenesis and progression of diabetes, particularly type 2 diabetes mellitus (T2DM). This review examined the complex interplay between genetic predispositions, lifestyle factors, and epigenetic changes that contributed to the development of diabetes and its complications. Key epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, can alter gene expression without changing the underlying DNA sequence, thereby influencing metabolic pathways essential for insulin sensitivity and β-cell function. Environmental factors such as diet, physical activity, and exposure to toxins induced epigenetic alterations, linking lifestyle choices to diabetes risk. Moreover, these modifications had significant implications for the development of microvascular and macrovascular complications associated with diabetes, including retinopathy and cardiovascular disease. Understanding the epigenetic landscape of diabetes not only enhanced our comprehension of its underlying mechanisms but also opened new avenues for therapeutic interventions. This review synthesized findings from recent literature and highlights the potential for targeting epigenetic modifications in developing personalized treatment strategies. A comprehensive analysis of studies published over the last decade, focusing on the relationship between epigenetics and diabetes. Keywords: Epigenetics, Type 2 Diabetes Mellitus (T2DM), DNA Methylation, Lifestyle Factors, Diabetic Complications.