Abstract
ObjectiveHepatic stellate cells (HSC) transdifferentiation into myofibroblasts is central to fibrogenesis. Epigenetic mechanisms, including histone and DNA methylation, play a key role in this process. Concerted action between histone and...
Highlights
The fibrogenic response is part of the natural reparative reaction in different tissues and organs
We found that G9a and DNMT1 protein levels were significantly induced between day 1 and day 4 of culture in parallel with -SMA, a marker of Hepatic stellate cells (HSC) myofibroblastic transdifferentiation
We found an overall impairment of transforming growth factor- (TGF) -activated profibrogenic gene expression, an effect that was strong upon G9a downregulation (Fig. 2C)
Summary
The fibrogenic response is part of the natural reparative reaction in different tissues and organs. This process leads to the formation of a temporary extracellular matrix (ECM). When damage persists, as occurs in liver chronic viral infection, alcohol abuse or in nonalcoholic fatty liver disease, the equilibrium between ECM production and removal is lost resulting in excessive accumulation of a dense ECM rich in fibrillar collagens.[1]. 22 to loss of liver function, progression to cirrhosis and hepatocellular carcinoma development.[1,2]. The pathological relevance of liver fibrogenesis has driven very active research over the past decades.
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