Abstract
Cholangiocarcinoma can cause obstructive jaundice which should be discriminated from other benign diseases. Recently, cholangioscope and cytology study are used for diagnosis with high specificity; however, the sensitivity of these examinations is quite low. The use of DNA marker such as methylation may help with the diagnosis. HOXA1 and RASSF1A genes are interesting targets since they are tumor suppressor genes, which usually have hypermethylated promoter during carcinogenesis. Analysis of these genes indicated that DNA methylation status of HOXA1promoter but not RASSF1A may be useful for diagnosis of cholangiocarcinoma in biliary obstruction patients.
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