Abstract
Bidirectional cross-talk between nuclear and mitochondrial DNA is fundamental for cell homeostasis. Epigenetic mechanisms regulate the inter-organelle communication between nucleus and mitochondria. Recent research highlights not only the retrograde activation of nuclear gene transcription in case of mitochondria dysfunction, but also the role of post-translational modifications of mitochondrial proteins in respiratory metabolism. Here we discuss some aspects and novel findings in Saccharomyces cerevisiae. In yeast, KAT-Gcn5 and DUB-Ubp8 have a role in respiration and are localized, as single proteins, into mitochondria. These findings, beside the canonical and widely known nuclear activity of SAGA complex in chromatin regulation, provide novel clues on promising aspects linking evolutionary conserved epigenetic factors to the re-programmed metabolism of cancer cells.
Highlights
The recent interest in non-disruptive therapy as a novel approach for treating refractory and metastatic cancers is a new perspective to tackle advanced neoplasia
Redirecting cells to differentiation aims to gain a novel apoptotic control avoiding adverse events and toxicity of more aggressive therapies. This principle has been comprehensively defined in the term Anakoinosis proposed by A
We would like to discuss some clues and novel evidences regarding the epigenetic regulation of respiratory functions found in yeast Saccharomyces cerevisiae
Summary
The recent interest in non-disruptive therapy as a novel approach for treating refractory and metastatic cancers is a new perspective to tackle advanced neoplasia. The identification of single oncogenes and tumor targets boost advances in personalized therapies often tumor recurrence and decreased efficacy of chemotherapy due to high genetic heterogeneity especially at metastatic sites (Gerlinger et al, 2012; Almendro et al, 2014) For these reasons, the pathway-epitope directed approaches is often correlated with the long-term failure of disruptive medicine. Based on the high evolutionary conservation from yeast to man, we can take advantages from discoveries in yeast to find similarities with human cells Cancer cells reprogram their metabolism to promote growth, survival and proliferation with aerobic glycolysis and show alterations in the mitochondrial functions affecting tumor survival. Absence of Gcn or chemical inhibition with KAT inhibitors of yeast cells
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