Abstract
Immunogenomics Initiation of immunoglobulin class switching and somatic hypermutation during B cell activation requires tightly regulated expression of the activation-induced cytidine deaminase ( Aicda ) gene. Lio et al. investigated how the enzymes responsible for depositing 5-hydroxymethylcytosine epigenetic marks on genomic DNA (TET2 and TET3) contribute to regulation of Aicda expression by studying B cells from mice in which the two enzymes can be inducibly deleted. Two key elements within the Aicda superenhancer are marked by TET2 and TET3 for progressive hydroxymethylation followed by demethylation, thereby facilitating chromatin accessibility and Aicda expression. Sci. Immunol. 4 , eaau7523 (2019).
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