Abstract
Dramatic fluctuations of estradiol and progesterone occur over the course of the menstrual cycle. Estradiol impacts expression of a number of genes related to reward and social behavior, including oxytocin receptor (OXTR), though the molecular mechanisms behind this regulation remains unclear. DNA methylation of the oxytocin receptor gene (OXTRm) is an epigenetic modification that is variable in humans and impacts gene expression, such that higher levels of OXTRm have been associated with reduced levels of OXTR expression. We investigate potential dynamics of OXTRm in women as a result of fluctuating ovarian hormones.
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