Abstract
Epigenetic Control of Reprogramming and Cellular Differentiation
Highlights
3 Institute of Predictive and Personalized Medicine of Cancer (IMPPC), 08916 Badalona, Spain 4 Sanford-Burnham Institute for Medical Research, La Jolla, CA 92037, USA Correspondence should be addressed to Pier Lorenzo Puri, plpuri@dti.telethon.it Received 7 August 2012; Accepted 7 August 2012
The focus of this review is to provide an overview of the epigenetic regulatory mechanisms controlling crucial cellular fate decisions, in particular during differentiation and reprogramming
Using skeletal muscle as a paradigm, they highlight the main discoveries obtained through the different methods and underline the advantages of an integrated approach to obtain a full picture of cellular differentiation
Summary
Daniela Palacios,[1] Sonia Forcales,[3] and Pier Lorenzo Puri[1, 4] 3 Institute of Predictive and Personalized Medicine of Cancer (IMPPC), 08916 Badalona, Spain 4 Sanford-Burnham Institute for Medical Research, La Jolla, CA 92037, USA Correspondence should be addressed to Pier Lorenzo Puri, plpuri@dti.telethon.it Received 7 August 2012; Accepted 7 August 2012 Numerous interdisciplinary approaches that include integration of bioinformatics, epigenetics, and molecular and cellular biology have started to shed light on the complex dynamics that regulate cellular processes such as cell “stemness,” reprogramming, and differentiation.
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